cdk2/cyclin a — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2029	Bohemine		ERK , CDK
	Bohemine is a cyclin-dependent kinase inhibitor.		ERK , CDK
T7426	ALSTERPAULLONE		Apoptosis , GSK-3 , CDK
	Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec		Apoptosis , GSK-3 , CDK
T14916	CDK2-IN-4		CDK
	CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86 uM.		CDK
T15335	FN-1501		FLT , CDK
	FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1501 also has anticancer activity.		FLT , CDK
T2059	Purvalanol A	NG-60	Apoptosis , CDK , Autophagy
	Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively.		Apoptosis , CDK , Autophagy
T7167	Purvalanol B	NG 95	CDK , Parasite
	Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)		CDK , Parasite
T2095	Seliciclib	Roscovitine,R-roscovitine,CYC202	CDK
	Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E (IC50: 0.1 μM). It also inhibits Cdk7/cyclin H, Cdk5/p35, and Cdc2/cyclin B (IC50s: 0.49/0.16/0.65 μM).		CDK
T5200	Indirubin-3'-monoxime	Indirubin-3'-oxime	GSK-3 , Lipoxygenase , CDK
	Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E).		GSK-3 , Lipoxygenase , CDK
T21588	Olomoucine		ERK , CDK
	Olomoucine is an ATP competitive inhibitor of Cdk2/cyclin A, Cdc2/CyclinB, CDK2/CyclinE, CDK5/p35, and ERK1/p44 MAP kinase with IC50s of 7, 7, 7, 3 and 25 µM, respectively. Olomoucine regulates cell cycle and exhibits an...		ERK , CDK
T22260	Aminopurvalanol A		CDK
	Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 n...		CDK
T2378	RGB-286638 free base		GSK-3 , MEK , JAK , CDK
	RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 a...		GSK-3 , MEK , JAK , CDK
T34888	TL12-186	TL12 186,TL12186	CDK , Ligand for E3 Ligase
	TL12-186 is a Cereblon-dependent kinase degrader that degrades CDK, BTK, FLT3, Aurora and other kinases.TL12-186 inhibits CDK2/cyclin A and CDK9/cyclin T1 with IC50s of 73 and 55 nM, respectively.		CDK , Ligand for E3 Ligase
T8796	CAN508		CDK
	CAN508 is a potent, ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. It is also a competitive inhibitor of Cdk2-cyclin E with respect to ATP, with Ki and IC50 values of 13.3 and 20 μM, respectively.CAN50...		CDK
T6787	BIO-acetoxime	BIA,GSK-3 Inhibitor X	Apoptosis , GSK-3 , HSV
	BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.		Apoptosis , GSK-3 , HSV
T2247	KenPaullone	9-Bromopaullone,NSC-664704	GSK-3 , CDK
	KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp...		GSK-3 , CDK
T16359	NU6140		CDK , Aurora Kinase
	NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also e...		CDK , Aurora Kinase
T8463	PF-06873600		CDK
	PF-06873600 is a selective and orally bioavailable cyclin-dependent kinase (CDK) inhibitor(CDK2, CDK4 and CDK6 with Ki of 0.09 nM, 0.13 nM and 0.16 nM, respectively), has potential antineoplastic activity.		CDK
T2679	BMS-265246	BMS265246	CDK
	BMS-265246 is a potent and selective CDK1/2 inhibitor.		CDK
T14943	CGP60474		VEGFR , CDK , PKC
	CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently.		VEGFR , CDK , PKC
T4321	Indisulam	E 7070	CDK , Carbonic Anhydrase
	Indisulam (E 7070) is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in th...		CDK , Carbonic Anhydrase